15th Annual · January 2017 · In person

2017

32 faculty
39 recordings
31 slide decks

Symposium

Biological and Clinical Aspects of Disorders Presenting as MCI

Saturday, January 14, 2017 · 8:00 am - 7:30 pm

7:15 am - 8:15
Check-in and Continental Breakfast
8:15 - 8:30
Welcome Notes/Introduction to Symposium
Ranjan Duara, MD, FAANMount Sinai Medical Center, Miami Beach, FL
Watch 4 min

8:30 - 11:25

Session 1

Seeding and Spread in Neurodegenerative Diseases

Chair: Todd Golde, PhDUniversity of Florida, Gainesville, FL

8:30 - 8:35
Session Overview
Todd Golde, PhDUniversity of Florida, Gainesville, FL
8:35 - 9:05
Keynote KEYNOTE LECTURE: Mechanisms of Protein Seeding in Neurodegenerative Diseases
Lary Walker, PhDEmory University, Atlanta, GA
Watch 39 min Slides PDF
9:10 - 9:25
Prion-like Propagation of Alpha-synuclein Aggregates in the Brain of Wild-type Mice
Nolwen Rey, PhDVan Andel Institute, Grand Rapids, MI
Watch 22 min Slides PDF
9:30 - 9:45
Prion-like Mechanisms of Disease Progression on Alzheimer’s Disease: New Therapeutic Opportunities
David Borchelt, PhDUniversity of Florida, Gainesville, FL
Watch 27 min Slides PDF
9:50 - 10:15
BREAK
10:15 - 10:30
Network-Based Spread in AD: Evidence from Multi-Modal Human Neuroimaging
Gil Rabinovici, MDUniversity of California San Francisco, CA
Watch 21 min Slides PDF
10:35 - 10:50
Clinicopathologic Heterogeneity of Neurofibrillary Tangle Patterns
Melissa Murray, PhDMayo Clinic, Jacksonville, FL
Watch 26 min Slides PDF
10:55 - 11:25
Panel Discussion/Q&A
Watch 23 min

11:25 am - 3:15 pm

Session 2

Progression Rates in Preclinical and Prodromal Neurodegenerative Disorders

Chair: Ronald Petersen, MD, PhDMayo Clinic, Rochester, MN

11:25 am - 11:30
Session Overview
Ronald Petersen, MD, PhDMayo Clinic, Rochester, MN
11:30 - 12:00
Keynote Community Predictors of Progression in Preclinical and MCI Due to Alzheimer's Disease
Ronald Petersen, MD, PhDMayo Clinic, Rochester, MN
Watch 34 min Slides PDF
12:05 - 12:20
Cognitive Decline in Preclinical Alzheimer’s Disease
Elizabeth Mormino, PhDMassachusetts General Hospital, Boston, MA
Watch 15 min Slides PDF
12:25 - 12:40
Imaging Predictors of Progression (Amyloid and Tau PET)
Adam Fleisher, MD, MASEli Lilly & Co., Inc., Indianapolis, IN
Watch 16 min Slides PDF
12:45 - 1:45
LUNCH
1:45 - 2:00
CSF Predictors of Disease Progression
Anne Fagan, PhDWashington University in St Louis, MO
Watch 29 min Slides PDF
2:05 - 2:20
Modeling Progression in Neurodegenerative Diseases Using Network Connectivity
Ashish Raj, PhDWeill Medical College of Cornell University, New York, NY
Watch 26 min Slides PDF
2:25 - 2:45
Longitudinal Progression of Biomarkers and Clinical Symptoms in Dominantly Inherited AD
Eric McDade, DOWashington University in St Louis, MO
Jason Hassenstab, PhDWashington University in St Louis, MO
Watch 17 min Slides 1 PDF Slides 2 PDF
2:50 - 3:20
Panel Discussion/ Q&A
Watch 26 min
3:20 - 3:45
BREAK

3:45 - 6:15

Session 3

Sleep Disorders and MCI

Chair: Steven DeKosky, MDUniversity of Florida, Gainesville, FL

3:45 - 3:50
Session Overview
Steven DeKosky, MDUniversity of Florida, Gainesville, FL
3:50 - 4:05
Sleep, Aging, and Brain Health: Implications for Prevention
Adam Spira, PhDJohns Hopkins Bloomberg School of Public Health, Baltimore, MD
Watch 27 min Slides PDF
4:10 - 4:25
Poor Sleep before Dementia: A Risk Factor for Cognitive Decline and Clinical Conversion?
Bryce Mander, PhDUniversity of California, Berkeley, CA
Watch 24 min Slides PDF
4:30 - 5:00
Keynote KEYNOTE LECTURE: The Glymphatic System, Sleep and Neurodegeneration
Jeffrey Iliff, PhDOHSU, Portland, OR
Watch 33 min Slides PDF
5:05 - 5:20
Obstructive Sleep Apnea, MCI and AD: Is there a Direct Link?
Ricardo Osorio, MDNew York University Center on Brain Health, NY, NY
Watch 20 min Slides PDF
5:25 - 5:40
REM Sleep Behavior Disorder and Neurodegenerative Disease
Michael Howell, MD, MPHUniversity of Minnesota, Minneapolis, MN
Watch 23 min Slides PDF
5:45 - 6:15
Panel Discussion/ Q&A
Watch 14 min
6:15 - 8:00
Networking Reception

Workshop

Assessment of Neuropsychological Test Performance in Cross Cultural Studies

Sunday, January 15, 2017 · 8:30 am - 1:30 pm

7:30 am - 8:30
Continental Breakfast and Check-in

8:30 - 12:30

Chair: Mónica Rosselli, PhDFlorida Atlantic University

8:30 - 8:35
Welcome Notes
Ranjan Duara, MD, FAANMount Sinai Medical Center, Miami Beach, FL
8:35 - 8:40
Introduction
Mónica Rosselli, PhDFlorida Atlantic University, Davie, FL
8:40 - 9:05
Keynote KEYNOTE LECTURE: The E280A PS1 Paisa Mutation and Biomarkers
Francisco Lopera, MDUniversidad de Antioquia, Medellín, Colombia
Watch 29 min Slides PDF
9:10 - 9:25
Brain imaging and Biomarker Abnormalities in Cognitively-unimpaired Individuals with Autosomal-dominant Alzheimer's Disease
Yakeel Quiroz, PhDMassachusetts General Hospital, Boston, MA
Watch 9 min Slides PDF
9:30 - 9:45
The Development of Novel Cognitive Stress Paradigms for Detection of Early Cognitive Impairment in Cross-Cultural Research
David Loewenstein, PhD, ABPPUniversity of Miami, Miami, FL
Watch 22 min Slides PDF
9:50 - 10:05
Neuropsychological Test Performance in Spanish and English Speakers with Normal Cognition and MCI
Rosie Curiel Cid, PsyDUniversity of Miami, Miami, FL
Watch 16 min Slides PDF
10:10 - 10:40
BREAK
10:40 - 10:55
Culture, Bilingualism, Neuropsychological Tests, and Biomarkers in MCI and early AD
Mónica Rosselli, PhDFlorida Atlantic University, Davie, FL
Watch part 1 6 min Watch part 2 23 min Slides PDF
11:00 - 11:15
Education and Late-life Cognitive Health in Diverse Populations
Dan Mungas, PhDUniversity of California, Davis, CA
Watch 30 min Slides PDF
11:20 - 11:35
MCI in Latin American Countries
Ricardo Nitrini, MD, PhDFMUSP, São Paulo SP, Brazil
Watch 25 min Slides PDF
11:40 am - 12:00 pm
Concluding Remarks
Vladimir Hachinski, FRCP, FRCPC, CM, FRSCUniversity of Western Ontario, London, ON
Watch 13 min Slides PDF
12:00 - 12:30
Panel Discussion/Q&A
Moderator: Oscar Lopez, MD
Watch part 1 36 min Watch part 2 15 min
12:30 - 1:30
LUNCH

Public Forum

New Concepts in Alzheimeru2019s Cause, Progression and Therapy

Sunday, January 15, 2017 · 1:30 pm - 5:40 pm

1:00 - 1:30pm
Check-in and Refreshments

1:30 - 5:00

Chair: David Loewenstein, PhD, ABPPUniversity of Miami, Miami, FL

1:30 - 1:40
Welcome Notes
Ranjan Duara, MD, FAANMount Sinai Medical Center, Miami Beach, FL
Watch 4 min
1:40 - 2:10
Keynote KEYNOTE LECTURE: Research to Clinic--Alzheimer's Disease Participation in Clinical Trials
Maria Carrillo, PhDAlzheimer’s Association, Chicago, IL
Watch 41 min Slides PDF
2:10 - 2:15
Introduction
David Loewenstein, PhD, ABPPUniversity of Miami, Miami, FL
2:15 - 2:30
Basis of Therapeutic Trials in Alzheimer’s Disease
Reisa Sperling, MDMassachusetts General Hospital, Boston, MA
Watch 18 min Slides PDF
2:35 - 2:50
Declining Incidence of Alzheimer’s Disease – Is it Real?
Mary Ganguli, MD, MPHUniversity of Pittsburgh, Pittsburgh, PA
Watch 19 min Slides PDF
2:55 - 3:10
How Do Neurodegenerative Diseases Progress?
Lary Walker, PhDEmory University, Atlanta, GA
Watch 16 min Slides PDF
3:15 - 3:45
BREAK
3:45 - 4:00
The Glymphatic System and the Brain
Jeffrey Iliff, PhDOHSU, Portland, OR
Watch 17 min Slides PDF
4:05 - 4:20
Why Sleep Shouldn't Be Ignored in Alzheimer's Disease
Bryce Mander, PhDUniversity of California, Berkeley, CA
Watch 22 min Slides PDF
4:25 - 4:55
Panel Discussion and Q&A
Watch 36 min
4:55 - 5:00
Closing Notes
Ranjan Duara, MD, FAANMount Sinai Medical Center, Miami Beach, FL

Programs, recordings and slides as published at the time. Slides and recordings appear only where speakers chose to share them. Affiliations are as of 2017.