12th Annual · January 2014 · In person
2014
- 26 faculty
- 31 recordings
- 22 slide decks
Symposium
A-beta Deposition, Neurodegeneration and Cognitive Function in Normal and Abnormal Aging
Saturday, January 18, 2014 · 8:00 am - 7:30 pm
- 8:00 - 8:10 amIntroduction to the MCI Symposium 2014
- 8:15 - 8:55Keynote The Relationship between Ab Deposition, Neurodegeneration and Cognitive Function in Normal and Impaired Individuals
8:55 - 11:40 am
Mini-Symposium 1
A-beta Deposition, Neurodegeneration and Cognitive Function in Normal and Abnormal Aging Chair:
Chair: Chester Mathis, PhDUniversity of Pittsburgh
- 8:55 - 9:20Amyloid, Glucose Metabolism, and Longitudinal Change
- 9:20 - 9:45Beta Amyloid Deposition in Very Healthy Adults: Risk Factors and Cognitive Consequences
- 9:45 - 10:10The Role of Imaging Biomarkers in the Prediction of MCI and Dementia Due to AD
- 10:30 - 10:55Variation in the Sequence of AD Biomarkers According to Brain Regions and Genetic Factors
- 10:55 - 11:20Cognitive Correlates of Neurodegeneration Related to Beta-amyloid and Aging in Clinically Normal Individuals
- 11:20 - 11:45Clinical Implications of Concordant and Discordant Beta-Amyloid and Neurodegenerative Abnormalities in Mild Cognitive Impairment
- 11:45 am - 12:45 pm
1:45 - 4:30
Mini-Symposium 2
Approaches to Measuring Cognitive and Functional Change across the MCI Spectrum
Chair: David Loewenstein, PhD, ABPPUniversity of Miami
- 1:45 - 2:05Development of Novel Paradigms for Assessing and Monitoring Cognitive Change Across the MCI and PreMCI Spectrum
- 2:05 - 2:30Biomarker Values Predictive of Cognitive Decline in MCI: Baseline or Progression?
- 2:30 - 2:55Computer-based Assessment of Functional Performance in MCI
- 2:55 - 3:20On Cognitive Performance as the Endpoint in Clinical Trials
- 3:40 - 4:05Cognitive Trajectories Associated with β-amyloid Deposition in Normal Aging and MCI
- 4:05 - 4:30Probability of Transition To and From MCI: Models of Clinical and Cognitive Features
- 4:30 - 5:30
- 5:30 - 7:30NETWORKING RECEPTION
Workshop
Diagnostic Case Studies of Preclinical Alzheimeru2019s Disease (AD), MCI-AD and Probable AD
Sunday, January 19, 2014 · 8:30 am - 1:30 pm
- 8:30 - 8:35Introduction to the Workshop
- 8:35 - 9:15Keynote Challenges in the Diagnosis of Early Alzheimer’s Disease
9:15 - 11:30
DIAGNOSTIC CASE STUDIES OF PRECLINICAL AD, MCI-AD AND PROBABLE AD Cases with concordant and discordant biomarkers and clinical results will be discussed. Several cases with follow-up to autopsy will be included.
Chair: Howard Chertkow, MDMcGill University and Jewish General Hospital
- 9:15 - 9:35Case 1: Clinical Implications of Discordant Biomarkers
- 9:35 - 9:55
- 9:55 - 10:15Conflicting Biomarkers in Clinical Practice
- 10:15 - 10:30BREAK
- 10:30 - 10:50Longitudinal Cognitive and Imaging Changes in a 70 Y/O Woman with Initial Subjective Cognitive Concerns
- 10:50 - 11:10When Amyloid Imaging Isn’t Enough
- 11:10 - 11:30Biomarker Use to Assist in Diagnosis of Atypical MCI Presentations/ Imaging for identifying non-AD/ Imaging for Identifying Non-AD
- 11:30 am - 12:30 pmOpen Discussion
- 12:30 - 1:30LUNCH
Public Forum
The Role of Amyloid Imaging in the Diagnosis of Mild Cognitive Impairment
Sunday, January 19, 2014 · 1:30 pm - 5:30 pm
- 1:30 - 1:40 pm
- 1:40 - 2:00Introduction to the Educational Forum
2:00 - 4:25
Chair: Stephen Salloway, MD, MSThe Warren Alpert Medical School of Brown University
- 2:00 - 2:25Incorporating Biomarkers of Amyloid and Neurogeneration in Clinical Evaluation of Mild Cognitive Impairment
- 2:25 - 2:50The Role of Cognitive Reserve in the Clinical Presentation of Alzheimer’s Disease
- 2:50 - 3:10Break
- 3:10 - 3:35Amyloid Imaging in Healthy Aging: Impact on Brain Function and Cognition
- 3:35 - 4:00Challenges in the Diagnosis of Early Alzheimer’s Disease
- 4:00 - 4:25The Role of Amyloid Imaging in the Diagnosis of Mild Cognitive Impairment: Current Research and Clinical UtilityPanelists: Michael Devous, PhD, Keith Fargo, PhD, Adam Fleisher, MD, MAS, Dorene Rentz, PsyD, Stephen Salloway, MD, MS, David Wolk, MD
- 5:25 - 5:30Closing Notes
Programs, recordings and slides as published at the time. Slides and recordings appear only where speakers chose to share them. Affiliations are as of 2014.