24th Annual · April 2026 · Virtual
2026
- 23 faculty
- 27 recordings
Symposium
Friday, April 24, 2026
- 9:00 AMIntroductory Notes on the 23nd Annual MCI SymposiumRanjan Duara, MD, FAANMount Sinai Medical Center/Wien Center for Alzheimer's Disease and Memory Disorders
9:10 AM
Session 1
Integrating Biomarkers, Imaging, and Cognitive Detection in Real-World Diagnosis of Alzheimeru2019s Disease and Related Disorders
Chair: Ronald Petersen, MD, PhDMayo Clinic, Rochester
- 9:10Session Overview Focus: How clinicians combine blood biomarkers, imaging, and cognitive tools to diagnose and stage real patients.
- 9:25Blood-Based Biomarkers in Primary Care and Specialty Care: How to Use p-tau217, Aβ42/40, GFAP, and NfL in 2026
- 9:50Factors beyond AD Pathophysiology that Affect the Concentration & Interpretation of Diagnostic AD Blood Biomarkers
- 10:15Current and Future Imaging and Biomarker Approaches for Diagnosing Preclinical, Early, and Symptomatic Alzheimer’s Disease
- 10:40Communicating Blood Biomarker Results and Options for Management to the Patient
- 11:05Discussion
11:30
Session 2
Factors Influencing Performance of Anti-Amyloid Agents in the Short and Longer Term and the Role of Maintenance Treatment
Chair: Vijay Ramanan, MD, PhDMayo Clinic
- 11:30Session Overview Focus: Practical Management of Lecanemab, Donanemab, and Future Agents; ARIA; Real-World Data; Maintenance Therapy
- 11:45Real-World Effectiveness and Safety of Anti-Amyloid Therapies
- 12:10Update on Safe Use of Amyloid-lowering Antibodies
- 12:35Long-term Treatment with Anti-Amyloid Therapy: Applying Trial Data to Real-world Decisions about Effectiveness
- 1:00AI-Assisted Detection of Amyloid-Related Imaging Abnormalities (ARIA): Promise and Pitfalls
- 1:25Discussion
- 1:50Break
2:00
Session 3
The Role of Infection and Inflammation in Neurodegenerative Diseases
Chair: Pascal Geldsetzer, MD, PhD, MPHStanford University
- 2:00Session Overview Focus: Mechanisms → biomarkers → clinical implications → future therapeutic pathwaysi
- 2:05A Common Virus, Herpes Virus Simplex Type 1 (HSV1), Plays a Major Role in Alzheimer’s Disease
- 2:30Impact of Vaccination for Herpes Zoster, Influenza, Pneumococcal pneumonia, etc. on Risk for MCI and Dementia
- 2:55Specialized Microglia at the Brain-body Interface
- 3:20How Systemic Infections and Inflammation Accelerate Cognitive Decline
- 3:45The Effect of Shingles Vaccination at Different Stages of the Dementia Disease Course
- 4:05Group Discussion
- 4:30Concluding RemarksRanjan Duara, MD, FAANMount Sinai Medical Center/Wien Center for Alzheimer's Disease and Memory Disorder
- 4:45Symposium ends
Public Forum
Friday, May 1, 2026
- 10:00 - 10:10 AM
10:10 - 11:50 AM
Session 1
Biomarkers: What Your Tests Can Tell Us About Memory
Chair: Breton Asken, PhDUniversity of Florida
- 10:10 - 10:15 AMSession Overview
- 10:15 - 10:30 AMAccuracy of Biomarkers - Effect of Ethnicity/Race and Systemic Disease
- 10:35 - 10:50 AMChallenges in Using Biomarkers in Primary Care
- 10:55 AM - 11:15 AMDISCUSSION
11:15 AM - 12:20 PM
Session 2
Changing the Course: Disease Modifying Therapies Today and Tomorrow
Chair: Steven DeKosky, MDUniversity of Florida
- 11:15 - 11:20 AMSession Overview
- 11:20 - 11:35 AMPredictors of Efficacy of Anti-Amyloid Treatment
- 11:40 AM - 11:55 AMOverview of Currently Approved and in the Pipeline Agents for Alzheimer's Disease
- 12:00 - 12:20 PMDISCUSSION
12:20 - 1:25 PM
Session 3
Infection, Inflammation, and the Brain: What You Need to Know
Chair: Leonard Sokol, MDMount Sinai Medical Center
- 12:20 - 12:25 PMSession Overview
- 12:25 - 12:45 PMInfectious Agents and Systemic Inflammatory Disease Associated with Alzheimer’s Disease
- 12:50 - 1:00 PMDISCUSSION
- 1:00 - 1:10 PMConcluding Remarks
Programs, recordings and slides as published at the time. Slides and recordings appear only where speakers chose to share them. Affiliations are as of 2026.