23rd Annual · April 2025 · Virtual

2025

29 faculty
6 recordings

Symposium

Friday, April 25, 2025

Full recording 1 149 min Full recording 2 140 min Full recording 3 129 min

9:00 AM
Introductory Notes on the 23nd Annual MCI Symposium
Ranjan Duara, MD, FAANMt Sinai Medical Center/Wien Center for Alzheimer's Disease and Memory Disorders

9:15 AM - 11:30 PM

Session 1

SUCCESSFUL AGING OF THE BRAIN

Chair: Judy Pa, PhDUCSD

9:15
Session Overview
9:20
Keynote Machine Learning Methods for Understanding Heterogeneity of Brain Aging
Christos Davatzikos, PhDUniversity of Pennsylvania
Watch 28 min
9:50
Healthy Lifestyle and Cognition in Older Adults with Common Neuropathologies of Dementia
Bryan James, PhDRush University
Watch 20 min
10:10
Modifiable Risk Factors for Dementia in Canada
Howard Chertkow, MDUniversity of Toronto
Watch 21 min
10:30
A Novel Approach to Model the Genetic and Phenotypic Basis of Exceptional Human Longevity
Paola Sebastiani, PhDTufts University School of Medicine
Watch 19 min
10:50
Successful Aging in the 90+ Study
Maria Corrada, ScM, ScDUniversity of California, Irvine
Watch 24 min
11:10
Discussion
Watch 31 min
11:30 AM
Break

12:00 PM - 2:20 PM

Session 2

WHITE MATTER DISEASE OF THE BRAIN

Chair: Adam Brickman, PhDColumbia University

12:00
Session Overview
12:05
Keynote Etiology of White Matter Disease in Autosomal Dominant and Sporadic Alzheimer’s Disease in the DIAN Study
Jasmeer Chhatwal, MD, PhDHarvard/MGH
Watch 33 min
12:35
White Matter Abnormalities in Autosomal Dominant Alzheimer's Disease: Findings from the Colombia-Boston (COLBOS) Biomarker Study
Yakeel Quiroz, PhDHarvard/MGH
Watch 21 min
12:55
Remembering Dr. Francisco Lopera
Mónica Rosselli, PhDFlorida Atlantic University
Yakeel Quiroz, PhDHarvard/MGH
Watch 6 min
1:00
White Matter Hyperintensities: Can They Be Treated?
Christopher Filley, MDUniversity of Colorado School of Medicine
Watch 18 min
1:20
Cerebral Small Vessel Disease–Related Dementia: More Questions Than Answers
Fanny Elahi, MD, PhDIcahn School of Medicine at Mount Sinai
Watch 20 min
1:40
Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer’s Disease: Results from the HELIAD Study
Nikolaos Scarmeas, MD, MSColumbia University
Watch 23 min
2:00
Discussion
Watch 18 min

2:20 PM - 4:40 PM

Session 3

UPDATE ON ANTI-AMYLOID TREATMENTS

Chair: Ronald Petersen, MD, PhDMayo Clinic, Rochester

2:20
Session Overview
2:25
Keynote Updated AUC for Anti-amyloid Therapy
David Knopman, MDMayo Clinic, Rochester
Watch 29 min
3:00
Effect of Long-Term Maintenance Anti-amyloid Treatment
Christopher van Dyck, MDYale School of Medicine
Watch 23 min
3:20
Clinical “Real-World” Experience using Anti-amyloid Therapies
Lawrence Honig, MD, PhDColumbia University
Watch 23 min
3:40
Safe Use of Amyloid-Lowering Antibodies
Stephen Salloway, MD, MSBrown University
Watch 19 min
4:00
Prospects for Dual Anti-amyloid and Anti-tau Treatment for Alzheimer’s Disease
Courtney Lane-Donovan, MD, PhDUCSF
Watch 15 min
4:20
Group Discussion
Watch 19 min
4:40
Concluding Remarks
Ranjan Duara, MD, FAANMount Sinai Medical Center Miami
4:55
Symposium ends

Public Forum

Friday, May 2, 2025

Full recording 1 108 min Full recording 2 79 min Full recording 3 53 min

9:30 AM
Welcome and Introductions
Ranjan Duara, MD, FAANMount Sinai Medical Center
Watch 4 min

9:40 - 11:20

Session 1

SCREENING AND DIAGNOSIS OF ALZHEIMER'S DISEASE

Chair: Mary Ganguli, MD, MPHUniversity of Pittsburgh

9:40
Session Overview
9:45
Overview of the Stages of Impairment: Cognitive, Functional, Behavioral Impairment
Rosie Curiel Cid, PsyDUniversity of Miami
Watch 17 min
10:05
Cognitive and Functional Assessment
Kirsten Horne Crenshaw, PsyDUniversity of Miami
Watch 17 min
10:25
Behavioral Assessment
Elizabeth Crocco, MDUniversity of Miami
Watch 17 min
10:45
Blood and Imaging Biomarkers
Ranjan Duara, MD, FAANMount Sinai Medical Center
Watch 20 min
11:05
DISCUSSION
Watch 31 min

11:20 - 12:40

Session 2

OPTIMIZING SUCCESSFUL AGING

Chair: Glenn Smith, PhD, ABPPUniversity of Florida

11:20
Session Overview
11:25
Lessons from the 90+ Study
Maria Corrada, ScM, ScDUniversity of California, Irvine
Watch 22 min
11:45
Lessons from the New England Centenarian Study
Stacy Andersen, PhDBoston University
Watch 18 min
12:05
Brain Aging, Stroke and the Genetic Clock
Tatjana Rundek, MD, PhDUniversity of Miami
Watch 22 min
12:25
DISCUSSION
Watch 13 min

12:40 - 1:40

Session 3

NEW PHARMACOLOGICAL TREATMENTS FOR ALZHEIMER'S DISEASE

Chair: Steven DeKosky, MDUniversity of Florida

12:40
Session Overview
12:45
Developments in Anti-amyloid Treatments and Progress with Anti-Tau, GLP1 RA ( “Ozempic”, etc) and Other Agents
Jeffrey Cummings, MD, ScDUniversity of Nevada, Las Vegas
Watch 26 min
1:10
DISCUSSION
Watch 27 min
1:30
Concluding Remarks
Ranjan Duara, MD, FAANMount Sinai Medical Center
1:35
End

Programs, recordings and slides as published at the time. Slides and recordings appear only where speakers chose to share them. Affiliations are as of 2025.