Program
20th ANNUAL MILD COGNITIVE IMPAIRMENT SYMPOSIUM
Saturday, February 26, 2022 (10:00 am – 3:15 pm US Eastern Time)
Sunday, February 27, 2022 (10:00 am – 3:00 pm US Eastern Time)
THE ANNUAL ALZHEIMER’S PUBLIC EDUCATIONAL FORUM
Sunday, March 6, 2022 (1:30 pm – 3:30 pm US Eastern Time)
Schedule
MCI Symposium Program (Day 1)
Saturday, February 26, 2022
All times in US Eastern Time.
10:00
10:15
10:35
10:40
11:10
11:30
11:50
12:10
12:30
12:50
13:00
13:05
13:35
13:55
14:15
14:35
14:55
15:15
Introductory Notes on the 20th Annual MCI Symposium
Reflection on the Concept of MCI and the Evolution of the Term “Adult Cognitive Disorders”
SESSION 1: COVID-19, MCI and Dementia
Keynote: The Global Effort to Study the Short-and Long-term consequences of SARS-CoV-2 on the CNS
Clinical Features and Plasma Biomarkers of Neurodegeneration and Neuroinflammation in Hospitalized COVID-19 Patients
Pathogenesis and Neurological Manifestations of COVID-19 Infection
Neurologic Post-acute Sequelae of SARS-CoV-2 Infection
Impact of COVID on Persons with AD: Focus on Hispanics/Native Americans
Panel Discussion/Q&A
Break
SESSION 2: Heterogeneity of Alzheimer’s Disease
Keynote: Symptomatic, Cognitive and Biomarker Heterogeneity in the Preclinical and Prodromal Stages of Alzheimer’s Disease
LATE: What It Is and Relevance to MCI
Genomic Heterogeneity in AD
A Multiomics Approach to Heterogeneity in Alzheimer’s
Embracing Heterogeneity in Early-phase Clinical Trial Designs for AD/ADRD
Panel Discussion/Q&A
End of Day 1
Ranjan Duara, MD, MRCP, FAAN
Mount Sinai Medical Center
Mount Sinai Medical Center
Ron Petersen, MD, PhD
Mayo Clinic
Mayo Clinic
Chair: Sudha Seshadri, MD
UTHSCSA
UTHSCSA
Sudha Seshadri, MD
UTHSCSA
UTHSCSA
Thomas Wisniewski, MD
New York University
New York University
Serena Spudich, MD, MA
Yale University
Yale University
Igor Koralnik, MD
Northwestern University
Northwestern University
Gabriel Erausquin, MD, PhD, MSc
UTHSCSA
UTHSCSA
Panel Discussion/Q&A
Break
Chair: Steve DeKosky, MD
University of Florida
University of Florida
David Wolk, PhD
University of Pennsylvania Perelman School of Medicine
University of Pennsylvania Perelman School of Medicine
Peter Nelson, MD, PhD
University of Kentucky College of Med.
University of Kentucky College of Med.
Nilüfer Ertekin-Taner, MD, PhD
Mayo Clinic
Mayo Clinic
Amanpreet Badhwar, PhD
University of Montreal
University of Montreal
Steven Arnold, MD
MGH, Harvard
MGH, Harvard
Panel Discussion/Q&A
End of Day 1
MCI Symposium Program (Day 2)
Sunday, February 27, 2022
All times in US Eastern Time.
10:00
10:05
10:35
10:55
11:15
11:35
11:55
12:15
12:35
12:45
12:50
13:20
13:40
14:00
14:20
14:40
15:00
15:15
SESSION 3: Predicting Progression & Cognitive Decline in AD and Impact on Clinical Trial Design
Keynote: Regional Accumulation of Tau in the Brain is a Major Determinant of Rate of Progression
Novel Approaches to Efficiently Identify Progression to SCD and MCI for AD Clinical Research
The Role of Brain Connectivity in the Spreading of Tau Pathology in AD
Preserving Cognitive Reserve with Social Interaction
Incorporating Factors Associated with Rate of Progression into the Design of AD Clinical Trials
Improved Designs for AD Clinical Treatment Trials
Panel Discussion/Q&A
Break
SESSION 4: Neuropsychiatric Features of MCI
Keynote: Will Targeting Neuropsychiatric Symptoms in Prodromal AD Delay or Prevent Progression to Dementia?
Challenges in the Measurement of Neuropsychiatric Symptoms (NPS) in MCI and Dementia (Caregiver Report and Objective Assessment)
Association of Biomarkers (sMRI, fMRI, FDG-PET, Amyloid PET, Tau PET) with Neuropsychiatric Symptoms in MBI, MCI and Dementia
Mild Behavioral Impairment, Prevalence, Caregiver Burden and Management
Neuropsychiatric Features of Lewy Body Disease
Panel Discussion/Q&A
Concluding Remarks
END OF SYMPOSIUM
Chair: Philip Scheltens, MD, PhD
Amsterdam University Medical Centers
Amsterdam University Medical Centers
Bradley Hyman, MD, PhD
MGH/Harvard University
MGH/Harvard University
Rachel Nosheny, PhD
UCSF
UCSF
Nicolai Franzmeier, MD, PhD
University of Muenchen
University of Muenchen
Hiroko Dodge, PhD
OHSU
OHSU
Philip Scheltens, MD, PhD
Amsterdam University Medical Centers
Amsterdam University Medical Centers
Howard Feldman, MD, FRCP (C)
University of California, San Diego
University of California, San Diego
Panel Discussion/Q&A
Break
Chair: Mary Ganguli, MD, MPH
University of Pittsburgh
University of Pittsburgh
Constantine (Kostas) Lyketsos, MD, MHS
Johns Hopkins University
Johns Hopkins University
Matthew Peters, MD
Johns Hopkins University
Johns Hopkins University
Pedro Rosa-Neto, MD, PhD
McGill University
McGill University
Zahinoor Ismail, MD
University of Calgary
University of Calgary
Paul Donaghy, MD
Newcastle University
Newcastle University
Panel Discussion/Q&A
Ranjan Duara, MD, MRCP, FAAN
Mount Sinai Medical Center
Mount Sinai Medical Center
END OF SYMPOSIUM
Public Educational Forum Program
Sunday, March 6, 2022
1:30 PM US Eastern Time.
The Countdown Begins!
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